Calendrier
| 20/09/2020 | 21:00 | Real Sociedad de Fútbol | 0 | 0 | Real Madrid CF |
| 26/09/2020 | 21:00 | Real Betis Balompié | 2 | 3 | Real Madrid CF |
| 30/09/2020 | 21:30 | Real Madrid CF | 1 | 0 | Real Valladolid CF |
| 04/10/2020 | 16:00 | Levante UD | 0 | 2 | Real Madrid CF |
| 17/10/2020 | 18:30 | Real Madrid CF | 0 | 1 | Cádiz CF |
| 21/10/2020 | 18:55 | Real Madrid CF | 2 | 3 | FK Shakhtar Donetsk |
| 24/10/2020 | 16:00 | FC Barcelona | 1 | 3 | Real Madrid CF |
| 27/10/2020 | 22:00 | Borussia Mönchengladbach | 2 | 2 | Real Madrid CF |
| 31/10/2020 | 15:00 | Real Madrid CF | 4 | 1 | SD Huesca |
| 03/11/2020 | 22:00 | Real Madrid CF | 3 | 2 | FC Internazionale Milano |
| 08/11/2020 | 22:00 | Valencia CF | 4 | 1 | Real Madrid CF |
| 21/11/2020 | 17:15 | Villarreal CF | 1 | 1 | Real Madrid CF |
| 25/11/2020 | 22:00 | FC Internazionale Milano | 0 | 2 | Real Madrid CF |
| 28/11/2020 | 22:00 | Real Madrid CF | 1 | 2 | Deportivo Alavés |
| 01/12/2020 | 19:55 | FK Shakhtar Donetsk | 2 | 0 | Real Madrid CF |
| 05/12/2020 | 17:15 | Sevilla FC | 0 | 1 | Real Madrid CF |
| 09/12/2020 | 22:00 | Real Madrid CF | 2 | 0 | Borussia Mönchengladbach |
| 12/12/2020 | 22:00 | Real Madrid CF | 2 | 0 | Club Atlético de Madrid |
| 15/12/2020 | 23:00 | Real Madrid CF | 3 | 1 | Athletic Club |
| 20/12/2020 | 22:00 | SD Eibar | 1 | 3 | Real Madrid CF |
| 23/12/2020 | 20:45 | Real Madrid CF | 2 | 0 | Granada CF |
| 30/12/2020 | 22:30 | Elche CF | 1 | 1 | Real Madrid CF |
| 02/01/2021 | 22:00 | Real Madrid CF | 2 | 0 | RC Celta de Vigo |
| 09/01/2021 | 22:00 | CA Osasuna | 0 | 0 | Real Madrid CF |
| 23/01/2021 | 22:00 | Deportivo Alavés | 1 | 4 | Real Madrid CF |
| 30/01/2021 | 17:15 | Real Madrid CF | 1 | 2 | Levante UD |
| 06/02/2021 | 17:15 | SD Huesca | 1 | 2 | Real Madrid CF |
| 09/02/2021 | 22:00 | Real Madrid CF | 2 | 0 | Getafe CF |
| 14/02/2021 | 17:15 | Real Madrid CF | 2 | 0 | Valencia CF |
| 20/02/2021 | 22:00 | Real Valladolid CF | 0 | 1 | Real Madrid CF |
| 24/02/2021 | 22:00 | Atalanta BC | 0 | 1 | Real Madrid CF |
| 01/03/2021 | 22:00 | Real Madrid CF | 1 | 1 | Real Sociedad de Fútbol |
| 07/03/2021 | 17:15 | Club Atlético de Madrid | 1 | 1 | Real Madrid CF |
| 13/03/2021 | 17:15 | Real Madrid CF | 2 | 1 | Elche CF |
| 16/03/2021 | 22:00 | Real Madrid CF | 3 | 1 | Atalanta BC |
| 20/03/2021 | 17:15 | RC Celta de Vigo | 1 | 3 | Real Madrid CF |
| 03/04/2021 | 16:15 | Real Madrid CF | 2 | 0 | SD Eibar |
| 06/04/2021 | 21:00 | Real Madrid CF | 3 | 1 | Liverpool FC |
| 10/04/2021 | 21:00 | Real Madrid CF | 2 | 1 | FC Barcelona |
| 14/04/2021 | 21:00 | Liverpool FC | 0 | 0 | Real Madrid CF |
| 18/04/2021 | 21:00 | Getafe CF | 0 | 0 | Real Madrid CF |
| 21/04/2021 | 22:00 | Cádiz CF | | | Real Madrid CF |
| 24/04/2021 | 21:00 | Real Madrid CF | | | Real Betis Balompié |
| 27/04/2021 | 21:00 | Real Madrid CF | | | Chelsea FC |
| 01/05/2021 | 21:00 | Real Madrid CF | | | CA Osasuna |
| 05/05/2021 | 21:00 | Chelsea FC | | | Real Madrid CF |
| 09/05/2021 | 21:00 | Real Madrid CF | | | Sevilla FC |
| 13/05/2021 | 22:00 | Granada CF | | | Real Madrid CF |
| 17/05/2021 | 02:00 | Athletic Club | | | Real Madrid CF |
| 24/05/2021 | 02:00 | Real Madrid CF | | | Villarreal CF |