| 19/08/2018 | 22:15 | Real Madrid CF | 2 | 0 | Getafe CF |
| 26/08/2018 | 22:15 | Girona FC | 1 | 4 | Real Madrid CF |
| 01/09/2018 | 20:45 | Real Madrid CF | 4 | 1 | CD Leganés |
| 15/09/2018 | 20:45 | Athletic Club | 1 | 1 | Real Madrid CF |
| 19/09/2018 | 21:00 | Real Madrid CF | 3 | 0 | AS Roma |
| 22/09/2018 | 20:45 | Real Madrid CF | 1 | 0 | RCD Espanyol de Barcelona |
| 26/09/2018 | 22:00 | Sevilla FC | 3 | 0 | Real Madrid CF |
| 29/09/2018 | 20:45 | Real Madrid CF | 0 | 0 | Club Atlético de Madrid |
| 02/10/2018 | 21:00 | PFC CSKA Moskva | 1 | 0 | Real Madrid CF |
| 06/10/2018 | 18:30 | Deportivo Alavés | 1 | 0 | Real Madrid CF |
| 20/10/2018 | 13:00 | Real Madrid CF | 1 | 2 | Levante UD |
| 23/10/2018 | 21:00 | Real Madrid CF | 2 | 1 | FC Viktoria Plzeň |
| 28/10/2018 | 17:15 | FC Barcelona | 5 | 1 | Real Madrid CF |
| 03/11/2018 | 17:15 | Real Madrid CF | 2 | 0 | Real Valladolid CF |
| 07/11/2018 | 22:00 | FC Viktoria Plzeň | 0 | 5 | Real Madrid CF |
| 11/11/2018 | 21:45 | RC Celta de Vigo | 2 | 4 | Real Madrid CF |
| 24/11/2018 | 14:00 | SD Eibar | 3 | 0 | Real Madrid CF |
| 27/11/2018 | 22:00 | AS Roma | 0 | 2 | Real Madrid CF |
| 01/12/2018 | 21:45 | Real Madrid CF | 2 | 0 | Valencia CF |
| 09/12/2018 | 17:15 | SD Huesca | 0 | 1 | Real Madrid CF |
| 12/12/2018 | 19:55 | Real Madrid CF | 0 | 3 | PFC CSKA Moskva |
| 15/12/2018 | 19:30 | Real Madrid CF | 1 | 0 | Rayo Vallecano de Madrid |
| 03/01/2019 | 22:30 | Villarreal CF | 2 | 2 | Real Madrid CF |
| 06/01/2019 | 19:30 | Real Madrid CF | 0 | 2 | Real Sociedad de Fútbol |
| 13/01/2019 | 21:45 | Real Betis Balompié | 1 | 2 | Real Madrid CF |
| 19/01/2019 | 17:15 | Real Madrid CF | 2 | 0 | Sevilla FC |
| 27/01/2019 | 21:45 | RCD Espanyol de Barcelona | 2 | 4 | Real Madrid CF |
| 03/02/2019 | 21:45 | Real Madrid CF | 3 | 0 | Deportivo Alavés |
| 09/02/2019 | 17:15 | Club Atlético de Madrid | 1 | 3 | Real Madrid CF |
| 13/02/2019 | 22:00 | AFC Ajax | 1 | 2 | Real Madrid CF |
| 17/02/2019 | 13:00 | Real Madrid CF | 1 | 2 | Girona FC |
| 24/02/2019 | 21:45 | Levante UD | 1 | 2 | Real Madrid CF |
| 02/03/2019 | 21:45 | Real Madrid CF | 0 | 1 | FC Barcelona |
| 05/03/2019 | 22:00 | Real Madrid CF | 1 | 4 | AFC Ajax |
| 10/03/2019 | 21:45 | Real Valladolid CF | 1 | 4 | Real Madrid CF |
| 16/03/2019 | 17:15 | Real Madrid CF | 2 | 0 | RC Celta de Vigo |
| 31/03/2019 | 20:45 | Real Madrid CF | 3 | 2 | SD Huesca |
| 03/04/2019 | 21:30 | Valencia CF | 2 | 1 | Real Madrid CF |
| 06/04/2019 | 16:15 | Real Madrid CF | 2 | 1 | SD Eibar |
| 15/04/2019 | 21:00 | CD Leganés | 1 | 1 | Real Madrid CF |
| 21/04/2019 | 16:15 | Real Madrid CF | 3 | 0 | Athletic Club |
| 25/04/2019 | 21:30 | Getafe CF | 0 | 0 | Real Madrid CF |
| 28/04/2019 | 20:45 | Rayo Vallecano de Madrid | 1 | 0 | Real Madrid CF |
| 05/05/2019 | 16:15 | Real Madrid CF | 3 | 2 | Villarreal CF |
| 12/05/2019 | 18:30 | Real Sociedad de Fútbol | 3 | 1 | Real Madrid CF |
| 19/05/2019 | 12:00 | Real Madrid CF | 0 | 2 | Real Betis Balompié |