| 14/08/2021 | 22:00 | Deportivo Alavés | Real Madrid CF | ||
| 22/08/2021 | 22:00 | Levante UD | Real Madrid CF | ||
| 28/08/2021 | 22:00 | Real Betis Balompié | Real Madrid CF | ||
| 12/09/2021 | 20:00 | Real Madrid CF | RC Celta de Vigo | ||
| 19/09/2021 | 20:00 | Valencia CF | Real Madrid CF | ||
| 22/09/2021 | 20:00 | Real Madrid CF | RCD Mallorca | ||
| 26/09/2021 | 20:00 | Real Madrid CF | Villarreal CF | ||
| 03/10/2021 | 20:00 | RCD Espanyol de Barcelona | Real Madrid CF | ||
| 17/10/2021 | 20:00 | Real Madrid CF | Athletic Club | ||
| 24/10/2021 | 20:00 | FC Barcelona | Real Madrid CF | ||
| 27/10/2021 | 20:00 | Real Madrid CF | CA Osasuna | ||
| 31/10/2021 | 21:00 | Elche CF | Real Madrid CF | ||
| 07/11/2021 | 21:00 | Real Madrid CF | Rayo Vallecano de Madrid | ||
| 21/11/2021 | 21:00 | Granada CF | Real Madrid CF | ||
| 28/11/2021 | 21:00 | Real Madrid CF | Sevilla FC | ||
| 05/12/2021 | 21:00 | Real Sociedad de Fútbol | Real Madrid CF | ||
| 12/12/2021 | 21:00 | Real Madrid CF | Club Atlético de Madrid | ||
| 19/12/2021 | 21:00 | Real Madrid CF | Cádiz CF | ||
| 02/01/2022 | 21:00 | Getafe CF | Real Madrid CF | ||
| 09/01/2022 | 21:00 | Real Madrid CF | Valencia CF | ||
| 19/01/2022 | 21:00 | Athletic Club | Real Madrid CF | ||
| 23/01/2022 | 21:00 | Real Madrid CF | Elche CF | ||
| 06/02/2022 | 21:00 | Real Madrid CF | Granada CF | ||
| 13/02/2022 | 21:00 | Villarreal CF | Real Madrid CF | ||
| 20/02/2022 | 21:00 | Real Madrid CF | Deportivo Alavés | ||
| 27/02/2022 | 21:00 | Rayo Vallecano de Madrid | Real Madrid CF | ||
| 06/03/2022 | 21:00 | Real Madrid CF | Real Sociedad de Fútbol | ||
| 13/03/2022 | 21:00 | RCD Mallorca | Real Madrid CF | ||
| 20/03/2022 | 21:00 | Real Madrid CF | FC Barcelona | ||
| 03/04/2022 | 20:00 | RC Celta de Vigo | Real Madrid CF | ||
| 10/04/2022 | 20:00 | Real Madrid CF | Getafe CF | ||
| 17/04/2022 | 20:00 | Sevilla FC | Real Madrid CF | ||
| 20/04/2022 | 20:00 | CA Osasuna | Real Madrid CF | ||
| 01/05/2022 | 20:00 | Real Madrid CF | RCD Espanyol de Barcelona | ||
| 08/05/2022 | 20:00 | Club Atlético de Madrid | Real Madrid CF | ||
| 11/05/2022 | 20:00 | Real Madrid CF | Levante UD | ||
| 15/05/2022 | 20:00 | Cádiz CF | Real Madrid CF | ||
| 22/05/2022 | 20:00 | Real Madrid CF | Real Betis Balompié |